Base de dados : HANSEN
Pesquisa : ANALISE POR CONGLOMERADOS [Descritor de assunto]
Referências encontradas : 6 [refinar]
Mostrando: 1 .. 6   no formato [Detalhado]

página 1 de 1

  1 / 6 HANSEN  
              next record last record
seleciona
para imprimir
Id:22676
Autor:Mohammad, Hatta
Título:Epidemiology of leprosy: molecular, biological, and immunological approach
..-
Fonte:s.l; s.n; 2003. 10 p. tab.
Resumo:Leprosy is an infectious disease for which humans are considered the only source of infection. The major hindrance in leprosy control and thus in reaching the elimination goal is that numerous leprosy cases remain undetected for a long time. Many of these patients are a continuous source of infection and, and hence perpetuate transmission. The goal of the World Health Organization (WHO) is to eliminate leprosy as a public problem by the year 2000; that is, to reach as a global prevalence of <1 per 10,000 people. The epidemiological data generated routinely by health services are greatly influenced by their policies and activities. The data do not, however necessarily reflect the true situation in the field. Information on the magnitude of the leprosy problem in any one area is important for the health services with regard to their planning, monitoring and evaluation of leprosy control activities. Our studies have suggested that the high prevalence of antibodies in children may be indicative of the active transmission of M. leprae in their surroundings. The prevalence of these antibodies may also be important for leprosy control programs in order to detect new patients as early as possible and in an effective and sustainable manner. Based on PCR data, it seems that the environment also plays an important role in the transmission of leprosy in endemic areas. The results of our study show that contact with a leprosy patient is the major determinant in the incidence of leprosy and that this concept shows similarities with the "stone-in-the-pond" principle of tuberculosis transmission in concentric circle around patients. (AU).
Descritores:Anticorpos
Análise por Conglomerados
DNA Bacteriano
Predisposição Genética para Doença/*GE
Geografia
Incidência
Hanseníase/BL/*EP/TM
Mycobacterium leprae/GE/*PY
Prevalência
Estudos Soroepidemiológicos
Limites:Humano
Localização:BR191.1; 09176/s


  2 / 6 HANSEN  
              first record previous record next record last record
seleciona
para imprimir
Id:22674
Autor:Bleharski, Joshua R; Li, Huiying; Meinken, Cristoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L
Título:Use of genetic profiling in leprosy to discriminate clinical forms of the disease
..-
Fonte:s.l; s.n; 2003. 4 p. .
Resumo:Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU).
Descritores:Algoritmos
Análise por Conglomerados
Contagem de Colônia Microbiana
Citocinas/GE/ME
Perfilação da Expressão Gênica/*
Regulação da Expressão Gênica/*
Genes de Imunoglobulinas
Imunidade Celular
Imunidade Natural
Hanseníase Virchowiana/*CL/*GE/IM/PP
Hanseníase Tuberculóide/*CL/*GE/IM/PP
Macrófagos Alveolares/MI
Glicoproteínas de Membrana/IM
Mycobacterium tuberculosis/GD/IM
Análise de Sequência com Séries de Oligonucleotídeos
Reação em Cadeia da Polimerase
Análise de Componente Principal
Receptores da Superfície Celular/IM
Receptores Imunológicos/GE/ME
Limites:Humano
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
Regulação para Cima
Localização:BR191.1; 09174/s


  3 / 6 HANSEN  
              first record previous record next record last record
seleciona
para imprimir
Id:18504
Autor:Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L
Título:Use of genetic profiling in leprosy to discriminate clinical forms of the disease
..-
Fonte:s.l; s.n; Sep. 2003. 4 p. graf.
Resumo:Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU).
Descritores:HANSENIASE VIRCHOWIANA/clas
HANSENIASE VIRCHOWIANA/genet
HANSENIASE VIRCHOWIANA/imunol
HANSENIASE VIRCHOWIANA/fisiopatol
HANSENIASE TUBERCULOIDE/clas
HANSENIASE TUBERCULOIDE/genet
HANSENIASE TUBERCULOIDE/imunol
HANSENIASE TUBERCULOIDE/fisiopatol
CITOCINAS/genet
CITOCINAS/metab
PERFILACAO DA EXPRESSÃO GÊNICA
ANALISE POR CONGLOMERADOS
CONTAGEM DE COLÔNIA MICROBIANA
REGULACAO DA EXPRESSÃO GÊNICA
IMUNIDADE CELULAR
IMUNIDADE NATURAL
MACROFAGOS ALVEOLARES/microbiol
GLICOPROTEINAS DE MEMBRANA/imunol
MYCOBACTERIUM TUBERCULOSIS/cresc
MYCOBACTERIUM TUBERCULOSIS/imunol
REACAO EM CADEIA DA POLIMERASE
RECEPTORES IMUNOLOGICOS/genet
RECEPTORES IMUNOLOGICOS/metab
RECEPTORES DA SUPERFICIE CELULAR/imunol
REGULACAO PARA CIMA
 Análise de Componente Principal
 ALGORITMOS
 GENES DE IMUNOGLOBULINAS
 ANALISE DE SEQUÊNCIA COM SERIES DE OLIGONUCLEOTIDIOS
Limites:SUPPORT, NON-U.S. GOV'T
HUMANO
SUPPORT, U.S. GOV'T, P.H.S.
Meio Eletrônico: - .
Localização:BR191.1; 09142/s; BR191.1; 09145/s


  4 / 6 HANSEN  
              first record previous record next record last record
seleciona
para imprimir
Id:15668
Autor:Lapa, Tiago; Ximenes, Ricardo; Silva, Nilza Nunes; Souza, Wayner; Albuquerque, Maria de Fátima Militão; Campozana, Gisele
Título:Vigilância da hanseníase em Olinda. Brasil, utilizando técnicas de análise espacial
Leprosy surveillance in Olinda, Brazil, Using spatial analysis techniques-
Fonte:Rio de Janeiro; s.n; set-out., 2001. 10 p. tab, graf, mapas.
Descritores:HANSENIASE
HANSENIASE
ANALISE DE VARIANCIA
FATORES DE RISCO
FATORES SOCIO-ECONOMICOS
POPULAÇAO URBANA
ANALISE POR CONGLOMERADOS
Localização:BR191.1; 08443/s; BR191.1; 08685/s


  5 / 6 HANSEN  
              first record previous record next record last record
seleciona
para imprimir
Id:13891
Autor:Hatta, Mochammad; Van Beers, Stella M; Madjid, Baedah; Djumadi, Achmad; de Wit, Madeleine Y. L; Klatser, R
Título:Distribution and persistence of Mycobacterium leprae nasal carriage among a population in which leprosy is endemic in Indonesia
..-
Fonte:s.l; s.n; 1995. 5 p. ilus, tab.
Descritores:ADOLESCENCIA
ANTICORPOS ANTIBACTÉRIAS
PORTADOR
PORTADOR
CRIANÇA
CRECHES
PRÉ-ESCOLAR
ANALISE POR CONGLOMERADOS
SEGUIMENTOS
INDONÉSIA
HANSENIASE
HANSENIASE
HANSENIASE
MYCOBACTERIUM LEPRAE
NARIZ
REAÇAO EM CADEIA POR POLIMERASE
PREVALENCIA
Localização:BR191.1; 06784/s


  6 / 6 HANSEN  
              first record previous record
seleciona
para imprimir
Id:13314
Autor:Myint, Tin; Htoon, Myo Thet; Shwe, Tin
Título:Estimation of leprosy prevalence in Bago and Kawa Townships using two-stage probability proportionate to size sampling technique
..-
Fonte:s.l; s.n; 1992. 6 p. tab.
Descritores:ADOLESCENCIA
PRÉ-ESCOLAR
ANALISE POR CONGLOMERADOS
LEVANTAMENTOS EPIDEMIOLOGICOS
INDIA
LACTENTE
HANSENIASE
PREVALENCIA
PROBABILIDADE
Localização:BR191.1; 06476/s



página 1 de 1
   


Refinar a pesquisa
  Base de dados : HANSEN Formulário avançado   
Pesquisar por : Formulário livre   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6.1 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information